e-ISSN 2598-3849       print ISSN 2527-8878

Vol 3, No 1 (2018)


Septiara Putri, Ery Setiawan, Siti Rizny F Saldi, Levina Chandra, Amila Megraini, Vetty Yulianty P


 ABSTRACTColorectal cancer is fairly common compared to other cancers. The incidence and mortality rates are predicted to increase globally. In some cases, cancer can be potentially spread to another organ or metastatic. One of recent available targeted therapies for metastatic colorectal cancer (mCRC) patient is Cetuximab (Erbitux ®), combined with chemotherapy. Despite clinical effectiveness, there is the importance of the evidence related cost-effectiveness of therapy. This study aims to summary, synthesize, and systematically review the economic evaluation studies of Cetuximab for metastatic colorectal cancer (mCRC). Model based economic evaluation of Cetuximab for metastatic colorectal cancer will be searched and included in the review based on specific eligibility criteria. Several electronic databases that will be used: Medline, Embase, Cochrane, National Institute of Health Research (NIHR) Center for Reviews and Dissemination. Full economic evaluation evidence will be summarized and critically appraised using Drummond as well as (Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. In terms of analysis, we will qualitatively appraise and present the studies that meet our inclusion and exclusion criteria. We are expected to summarize the quality and capture the valuable insights related to health economic evaluation studies of Cetuximab for mCRC patient. ABSTRAKKanker kolorektal cukup umum terjadi dibandingkan kanker lainnya, angka kejadian dan angka kematian diprediksi meningkat secara global. Dalam beberapa kasus, kanker berpotensi menyebar ke organ lain atau disebut metastasis. Salah satu terapi yang ditargetkan baru-baru ini untuk pasien kanker kolorektal metastatik (mCRC) adalah Cetuximab (Erbitux®), yang dikombinasikan dengan kemoterapi. Meskipun terdapat bukti klinis, penting untuk mempertimbangkan bukti terkait efektivitas biaya dari terapi tersebut. Penelitian ini bertujuan untuk merangkum, mensintesis, dan meninjau secara sistematis studi evaluasi ekonomi Cetuximab untuk kanker kolorektal metastatik (mCRC). Evaluasi ekonomi berbasis model untuk menilai Cetuximab pada kanker kolorektal metastatik akan ditelusuri sesuai dengan kriteria yang ditetapkan. Beberapa database elektronik yang akan digunakan: Medline, Embase, Cochrane, Pusat Penelitian Kesehatan Nasional (NIHR) untuk Tinjauan dan Diseminasi. Bukti evaluasi ekonomi lengkap akan dirangkum dan dinilai secara kritis dengan menggunakan daftar pertanyaan oleh Drummond dan juga Consolidated Health Economic Evaluation Reporting Standards (CHEERS). Dalam hal analisis, kami akan menilai dan menyajikan secara kualitatif studi yang memenuhi kriteria inklusi dan eksklusi. Kami berekspektasi untuk meyimpulkan kualitas dan menangkap informasi yang berkaitan dengan studi evaluasi ekonomi pada Cetuximab untuk pasien mCRC.


economic evaluation; cetuximab; erbitux; colorectal cancer


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DOI: 10.7454/eki.v3i1.2304


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