1. Home
  2. Vol 3, No 2 (2019)
  3. Magfira

Association of Obesity and Negative Acid-Fast Bacilli Finding Among Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus

Nadya Magfira, Md Ikhsan Mokoagow, Ida Ayu Kshanti, Helda Helda

Abstract


Obesity is known as protective factors of pulmonary tuberculosis (PTB) innon-diabetes mellitus population. However, it’s effect on PTB in type 2diabetes mellitus (T2DM) patient is unclear. The study aims to determinethe association between obesity and PTB in patient with T2DM. A crosssectional study was held in in-patient, The Department of Internal Medicine, Fatmawati General Hospital from January 2015 to December 2017.This study includes patient with T2DM who had been diagnosed with PTBand age > 18 years old. In this study negative Acid-fast-bacilli (AFB)founding defined as patient’s sputum is negative by smear microscopy,while obesity define as body mass index > 24.9 kg/m2. From 363 PTBpatient with T2DM, 22.59% were obese. Results showed that prevalenceof negative AFB founding in PTB patients with T2DM was 81.82% and itwas solely associated with obesity (p:0.002, OR=6.36, 95%CI 1.9-21). Obesepatients were likely to have negative AFB founding. It suggested thatdiagnosing PTB in patient with T2DM and obese can’t be solely based onbacteriological confirmation

Keywords


Tuberculosis; Diabetes; Obesity; Acid-fast bacilli

Full Text:

PDF

References


WHO. Guideline on Management of Drug Resistance-TB.; 2018. doi:10.1001/jama.2014.11450

Kim SJ, Hong YP, Lew WJ, Yang SC, Lee EG. Tubercle and Lung Disease Incidence of pulmonary tuberculosis among diabetics. 1995;(September 1994):529-533.

K. P. AH, Ayoob MA. Impact of diabetes mellitus on clinical presentation and treatment response of smear positive pulmonary tuberculosis patients. Int J Res Med Sci. 2017;5(4):1245. doi:10.18203/2320-6012.ijrms20170977

WHO. Tuberculosis Facts- Tuberculosis and Diabetes. 2016. www.who.int/tb.

Al-Rifai RH, Pearson F, Critchley JA, Abu-Raddad LJ. Association between diabetes mellitus and active tuberculosis: A systematic review and meta-analysis. PLoS One. 2017;12(11):1-26. doi:10.1371/journal.pone.0187967

Lin HH, Wu CY, Wang CH, et al. Association of obesity, diabetes, and risk of tuberculosis: Two population-based cohorts. Clin Infect Dis. 2018;66(5):699-705. doi:10.1093/cid/cix852

Leung G, Law WS, Tam CM, Chan CK, Chang KC. Lower Risk of Tuberculosis in Obesity. 2015;167:1297-1304.

Williams BG, Cegielski P, Dye C. A consistent log-linear relationship between tuberculosis incidence and body mass index. 2010;(October 2009):149-155. doi:10.1093/ije/dyp308

Kim SJ, Ye S, Ha E, Chun EM. Association of body mass index with incident tuberculosis in Korea. PLoS One. 2018;13(4):1-12. doi:10.1371/journal.pone.0195104

O’Rourke RW, Kay T, Scholz MH, et al. Alterations in T-cell subset frequency in peripheral blood in obesity. Obes Surg. 2005;15(10):1463-1468. doi:10.1381/096089205774859308

Lai Y. Accepted Article Preview : Published ahead of advance online publication. 2017;(October 2016). doi:10.1038/ijo.2017.64

Farooqi IS, Depaoli AM, Rahilly SO, et al. Beneficial effects of leptin on obesity. J Clin Invest. 2002;110(8):1093-1103. doi:10.1172/JCI200215693.Introduction

Umakanth M, Rishikesavan S. Prevalence of diabetes mellitus among tuberculosis patient in Batticaloa district , Sri Lanka. 2017;2(2):21-23. doi:10.5588/pha.13.0024.5.

Mexitalia M, Dewi YO, Pramono A, Anam MS. Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children. Korean J Pediatr. 2017;60(4):118-123. doi:10.3345/kjp.2017.60.4.118

Çakır B, Yönem A, Güler S, et al. Relation of Leptin and Tumor Necrosis Factor α to Body Weight Changes in Patients with Pulmonary Tuberculosis. Horm Res Paediatr. 1999;52(6):279-283. doi:10.1159/000023495

Procaccini C, Jirillo E, Matarese G. Leptin as an immunomodulator. Mol Aspects Med. 2012;33(1):35-45. doi:10.1016/j.mam.2011.10.012




DOI: http://dx.doi.org/10.7454/epidkes.v3i2.3470

Refbacks

  • There are currently no refbacks.