The Seroprevalence of Toxoplasma gondii in Cats at the House of Maternal Women with Toxoplasmosis in Badung, Indonesia

Made Subrata, Nyoman Mantik Astawa, Nyoman Tigeh Suryadi, Sang Gede Purnama, Kadek Karang Agustina, Ngakan Putu Anom Harjana, Made Damriyasa

Abstract


Toxoplasmosis is a zoonotic disease caused by infection with the parasite called Toxoplasma gondii (T. gondii). The health and social impacts of the infectionare enormous, including miscarriage, hydrocephalus, blindness, and mental retardation. The occurrence of toxoplasmosis in maternal women cannot be se parated from cats around their houses. This study aimed to determine the seroprevalence of the parasite in cats found in the human carriers residences and identify the risk factors of toxoplasmosis in maternal women in Badung District, Bali Province, Indonesia. A total of 80 cat serum samples were obtained from two residential groups, 40 from the housing where the maternal women were infected and another 40 from where there were no identified sufferers of the disease. All the samples were examined using the enzyme-linked immunosorbent assay (ELISA) method to detect the presence of antibodies T. gondiiin feralcat serum. The results showed that 47.5% of the examined subjects had the said antibodies. As much as 65% came from housing with cases of toxoplasmosisin maternal mothers, and 30% came from residences with none. The presence of feral cats is a major risk factor for the transmission of T. gondiito humans.


Keywords


cats, maternal women, risk factor, Toxoplasma gondii, toxoplasmosis

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References


 1. Flegr J, Prandota J, Sovičková M, Israili ZH. Toxoplasmosis-a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One. 2014; 9 (3): 1–22.

 2. El-Bissati K, Levigne P, Lykins J, Adlaoui EB, Barkat A, Berraho A, et al. Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis. Emerging Microbes & Infections. 2018; 7 (1): 1–14.

 3. Aguirre AA, Longcore T, Barbieri M, Dabritz H, Hill D, Klein PN, et al. The one health approach to toxoplasmosis: epidemiology, control, and prevention strategies. Ecohealth. 2019; 16 (2): 378–90.

 4. Molan A, Nosaka K, Hunter M, Wang W. Global status of Toxoplasma gondii infection: systematic review and prevalence snapshots. Tropical Biomedicine. 2019; 36 (4): 898–925.

 5. Luc Paris. Toxoplasmosis. Hunter's Tropical Medicine and Emerging Infectious Disease. 2020; 10 (106): 803–13.

 6. Chomel BB, Kasten R, Adams C, Lambillotte D, Theis J, Goldsmith R, et al. Serosurvey of some major zoonotic infections in children and teenagers in Bali, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health. 1993; 24 (2): 321–6.

 7. Matsuo K. Investigation of toxoplasma gondii antibody in human in Bandar Lampung. Bulletin BPPH III Lampung. 1995; 11: 1–6.

 8. Uga S, Ono K, Kataoka N, Hasan H. Seroepidemiology of five major zoonotic parasite infections in inhabitants of Sidoarjo, East Java, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health. 1996; 27: 556–61.

 9. Fan CK, Su KE, Wu GH, Chiou HY. Seroepidemiology of Toxoplasma gondii infection among two mountain Aboriginal populations and Southeast Asian laborers in Taiwan. Journal of Parasitology. 2002; 88(2): 411–4.

 10. Dwinata IM, Sutarga IM, Damriyasa IM. The potential risk factors for toxoplasmosis in Balinese pregnant women-Indonesia. Bali Medical Journal. 2016; 5 (1): 116–8.

 11. Retmanasari A, Widartono BS, Wijayanti MA, Artama WT. Prevalence and risk factors for toxoplasmosis in Middle Java, Indonesia. Ecohealth. 2017; 14 (1): 162–70.

 12. Tuda J, Adiani S, Ichikawa-Seki M, Umeda K, Nishikawa Y. Seroprevalence of Toxoplasma gondii in humans and pigs in North Sulawesi, Indonesia. Parasitology International. 2017; 66 (5): 615–8.

 13. Sukaryawati P. Faktor risiko kejadian toksoplasmosis pada ibu hamil di wilayah Kecamatan Mengwi Kabupaten Badung tahun 2011. Program Studi Kesehatan Masyarakat Fakultas Kedokteran Universitas Udayana; 2011.

 14. Laksemi DAAS, Artama W tunas, Wijayanti MA. Seroprevalensi yang tinggi dan faktor-faktor risiko toksoplasmosis pada darah donor dan wanita di Bali. Jurnal Veteriner. 2013; 14 (2): 204–12.

 15. Eka Febianingsih NP, Indriani C, Artama WT. Seroprevalensi toksoplasmosis di Kabupaten Gianyar, Bali. Berita Kedokteran Masyarakat.2017; 33 (2): 61.

 16. Subrata IM, Suryadhi NT, Mantik-Astawa N, Damriyasa IM. Epidemiological and molecular analysis of Toxoplasma gondii in faecal samples of cats obtained from house of maternal in Bali. Bali Medical Journal. 2015; 4 (2): 68–75.

 17. Wirata IW. Perbandingan predileksi sista Toxoplasma gondii pada jantung dan diafragma babi di Bali. Jurnal Sain Veteriner. 2014; 32 (2): 185–90.

 18. Dwinata IM, Oka IBM, Suratma NA, Damriyasa IM. Seroprevalensi dan isolasi Toxoplasma gondii pada ayam kampung di Bali. Veteriner. 2012; 13 (4): 340–4.

 19. Liu Q, Wei F, Gao S, Jiang L, Lian H, Yuan B, et al. Toxoplasma gondii infection in pregnant women in China. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2009; 103 (2): 162–6.

 20. Avelino MM, Campos D, Parada JB de, Castro AM de. Risk factors for Toxoplasma gondii infection in women of childbearing age. Brazilian Journal of Infectious Diseases. 2004; 8 (2): 164–74.

 21. Ayi I, Edu S, Apea-kubi K, Boamah D, Bosompem K, Edoh D. Seroepidemiology of toxoplasmosis amongst pregnant women in the greater Accra region of Ghana. Ghana Medical Journal. 2010; 43 (3): 107–14.

 22. Fonseca AL, Silva RA, Fux B, Madureira AP, de Sousa FF, Margonari C. Aspectos epidemiológicos da toxoplasmose e avaliação de sua soroprevalência em gestantes. Revista da Sociedade Brasileira de Medicina Tropical. 2012; 45 (3): 357–64.

 23. Van Wormer E, Fritz H, Shapiro K, Mazet JAK, Conrad PA. Moleculesto modeling: Toxoplasma gondii oocysts at the human-animal-environment interface. Comparative Immunology, Microbiology & Infectious Diseases. 2013; 36 (3): 217–31.

 24. Dabritz HA, Conrad PA. Cats and toxoplasma: implications for public health. Zoonoses Public Health. 2010; 57 (1): 34–52.

 25. Ayinmode AB, Obebe OO, Olayemi E. Prevalence of potentially zoonotic gastrointestinal parasites in canine faeces in Ibadan, Nigeria. Ghana Medical Journal. 2016; 50 (4): 201–6.

 26. Stelzer S, Basso W, Benavides Silván J, Ortega-Mora LM, Maksimov P, Gethmann J, et al. Toxoplasma gondii infection and toxoplasmosis in farm animals: risk factors and economic impact. Food and Waterborne Parasitology. 2019; 12 (2019): 1–32.

 27. Dubey JP. Toxoplasmosis of animals and humans. Toxoplasmosis of Animals and Humans. 2010.

 28. Bahia-Oliveira LMG, Jones JL, Azevedo-Silva J, Alves CCF, Oréfice F, Addiss DG. Highly endemic, waterborne toxoplasmosis in North Riode Janeiro State, Brazil. Emerging Infectious Diseases. 2003; 9 (1): 55–62.

 29. Heukelbach J, Meyer-Cirkel V, Moura RCS, Gomide M, Queiroz JAN, Saweljew P, et al. Waterborne toxoplasmosis, Northeastern Brazil. Emerging Infectious Diseases. 2007; 13 (2): 287–9.

 30. Ertug S, Okyay P, Turkmen M, Yuksel H. Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin Province, Turkey. BMC Public Health. 2005; 5 (66): 1–6.

 31. Gandahusada S. Study on the prevalence of toxoplasmosis in Indonesia. A Review. Southeast Asian Journal of Tropical Medicine and Public Health. 1991; 22: 93–8.

 32. Dwinata IM, Oka IBM, Agustina KK, Damriyasa IM. Seroprevalence of neospora caninum in local Bali dog. Veterinary World. 2018; 11(7): 926–9.

 33. Dahlan M. Besar sampel dan cara pengambilan sampel dalam penelitian kedokteran dan kesehatan. Jakarta: Penerbit Salemba Medika; 2009.

 34. Castillo-Morales VJ, Acosta Viana KY, Guzmán-Marín EDS, Jiménez-Coello M, Segura-Correa JC, Aguilar-Caballero AJ, et al. Prevalence and risk factors of toxoplasma gondii infection in domestic cats from the tropics of Mexico using serological and molecular tests. Interdisciplinary Perspectives on Infectious Diseases. 2012; 2012 (529108): 1–6.

 35. Nissapatorn V, Suwanrath C, Sawangjaroen N, Ling LY, Chandeying V. Toxoplasmosis-serological evidence and associated risk factors among pregnant women in Southern Thailand. American Journal of Tropical Medicine and Hygiene. 2011; 85 (2): 243.

 36. Rai SK, Kubo T, Yano K, Shibata H, Sumi K, Matsuoka A, et al. Seroepidemiological study of toxoplasma infection in central and western regions in Nepal. Southeast Asian Journal of Tropical Medicine and Public Health. 1996; 27 (3): 548–53.

 37. Al-Sray AH, Sarhan SR, Mohammed HA. Molecular and serological characterization of Toxoplasma gondiiin women in Wasit Province. Advances in Animal and Veterinary Sciences. 2019; 7 (8): 657–63.

 38. Fromont EG, Riche B, Rabilloud M. Toxoplasma seroprevalence in arural population in France: detection of a household effect. BMC Infectious Diseases. 2009; 9 (76): 1–7.

 39. Ferreira MU, Hiramoto RM, Aureliano DP, Da Silva-Nunes M, DaSilva NS, Malafronte RS, et al. A community-based survey of human toxoplasmosis in rural Amazonia: seroprevalence, seroconversion rate, and associated risk factors. American Journal of Tropical Medicine and Hygiene. 2009; 81 (1): 171–6.

 40. Lopes FMR, Mitsuka-Breganó R, Gonçalves DD, Freire RL, Karigyo CJT, Wedy GF, et al. Factors associated with seropositivity for anti-toxoplasma gondii antibodies in pregnant women of Londrina, Paraná, Brazil. Memórias do Instituto Oswaldo Cruz. 2009; 104 (2): 378–82.

 41. Kapperud G, Jenum PA, Stray-Pedersen B, Melby KK, Eskild A, Eng J. Risk factors for toxoplasma gondii infection in pregnancy: results of a prospective case-control study in Norway. American Journal of Epidemiology. 1996; 144 (4): 405–12.

 42. Egorov AI, Converse R, Griffin SM, Styles J, Klein E, Sams E, et al. Environmental risk factors for Toxoplasma gondii infections and the impact of latent infections on allostatic load in residents of Central North Carolina. BMC Infectious Diseases. 2018; 18 (421): 1–11.

 43. Smit GSA, Vu BTL, Do DT, Do QH, Pham HQ, Speybroeck N, et al. Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam. BMC Infectious Diseases. 2019; 19 (329): 1–8.

 44. Chaudhry SA, Gad N, Koren G. Toxoplasmosis and pregnancy. Canadian Family Physician. 2014; 60 (4): 334–6.

 45. Fenta DA. Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia. BMC Infectious Diseases. 2019; 19 (1): 1–9.

 46. Nayeri T, Sarvi S, Moosazadeh M, Amouei A, Hosseininejad Z, Daryani A. The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: a systematic review and meta-analysis. PLoS Neglected Tropical Diseases. 2020; 14 (3): 1–27.

 47. Mohamed K, Kodym P, Maly M, El-Rayah I. Environmental and food habitat risk factors associated with Toxoplasma gondii infection in rural women in Sudan. International Journal of Current Microbiology and Applied Sciences. 2014; 3 (2): 208–22.

 48. Khurana S, Bagga R, Aggarwal A, Lyngdoh V, Shivapriya, Diddi K, et al. Serological screening for antenatal toxoplasma infection in India. Indian Journal of Medical Microbiology. 2010; 28 (2): 143–6.

 49. Ekanayake S, Kurukulasuriya NT. Prevalence of antibodies to Toxoplasma gondii in pregnant women. Kandy Medical Journal. 1995; 4 (2): 36–40.

 50. Tenter AM. Toxoplasma gondii in animals used for human consumption. Memórias do Instituto Oswaldo Cruz. 2009; 104 (2): 364–9.

 51. Alizadeh AM, Jazaeri S, Shemshadi B, Hashempour-Baltork F, Sarlak Z, Pilevar Z, et al. A review on inactivation methods of Toxoplasma gondii in foods. Pathogens and Global Health. 2018; 112 (6): 306–19.

 52. Dong H, Su R, Lu Y, Wang M, Liu J, Jian F, et al. Prevalence, risk factors, and genotypes of Toxoplasma gondii in food animals and humans (2000-2017) from China. Frontiers in Microbiology. 2018; 9 (2108):1–10.

 53. López-Castillo CA, Díaz-Ramírez J, Gómez-Marín JE. Factores de riesgo en mujeres embarazadas, infectadas por Toxoplasma gondii en Armenia-Colombia. Revista de Salud Pública. 2005; 7 (2): 180–90.

 54. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. International Journal for Parasitology. 2000; 30 (12–13): 1217–58.




DOI: http://dx.doi.org/10.21109/kesmas.v16i4.4954

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