Association of Obesity and Negative Acid-Fast Bacilli Finding Among Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus

Nadya Magfira, Md Ikhsan Mokoagow, Ida Ayu Kshanti, Helda Helda

Abstract


Obesity is known as protective factors of pulmonary tuberculosis (PTB) in
non-diabetes mellitus population. However, it’s effect on PTB in type 2
diabetes mellitus (T2DM) patient is unclear. The study aims to determine
the association between obesity and PTB in patient with T2DM. A crosssectional study was held in in-patient, The Department of Internal Medicine, Fatmawati General Hospital from January 2015 to December 2017.
This study includes patient with T2DM who had been diagnosed with PTB
and age > 18 years old. In this study negative Acid-fast-bacilli (AFB)
founding defined as patient’s sputum is negative by smear microscopy,
while obesity define as body mass index > 24.9 kg/m2. From 363 PTB
patient with T2DM, 22.59% were obese. Results showed that prevalence
of negative AFB founding in PTB patients with T2DM was 81.82% and it
was solely associated with obesity (p:0.002, OR=6.36, 95%CI 1.9-21). Obese
patients were likely to have negative AFB founding. It suggested that
diagnosing PTB in patient with T2DM and obese can’t be solely based on
bacteriological confirmation


Keywords


Tuberculosis; Diabetes; Obesity; Acid-fast bacilli

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DOI: http://dx.doi.org/10.7454/epidkes.v3i2.3470

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